The Importance of Prions

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The Importance of Prions

While agent host-range and strain properties convinced early researchers of a viral etiology, the once unorthodox postulate that prion transmission occurs by conformational corruption of hostencoded cellular prion protein (PrP) by a pathogenic isoform (PrP) is now widely accepted. Indeed, conformational templating is increasingly understood to be a general mechanism of proteinmediated informati...

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The discovery of infectious proteins, denoted prions, was unexpected. After much debate over the chemical basis of heredity, resolution of this issue began with the discovery that DNA, not protein, from pneumococcus was capable of genetically transforming bacteria (Avery et al. 1944). Four decades later, the discovery that a protein could mimic viral and bacterial pathogens with respect to the ...

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Chronic wasting disease (CWD) affects cervids and is the only known prion disease readily transmitted among free-ranging wild animal populations in nature. The increasing spread and prevalence of CWD among cervid populations threaten the survival of deer and elk herds in North America, and potentially beyond. This review focuses on prion ecology, specifically that of CWD, and the current unders...

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ژورنال

عنوان ژورنال: PLoS Pathogens

سال: 2013

ISSN: 1553-7374

DOI: 10.1371/journal.ppat.1003090